Development of new thieno[2,3-d]pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities
Heba A. Elsebaie, Tarek F. El‐Moselhy, Eman A. El-Bastawissy, Kamel M. Elberembally, Rehab Mustafa Badi, Eslam B. Elkaeed, Moataz A. Shaldam, Wagdy M. Eldehna, Haytham O. Tawfik
Topics & Concepts
ChemistrySTAT3EGFR inhibitorsApoptosisCytotoxic T cellCancer researchSTAT proteinCell culturePharmacologyEpidermal growth factor receptorIn vitroBiochemistryBiologyReceptorGeneticsCytokine Signaling Pathways and InteractionsSynthesis and biological activityQuinazolinone synthesis and applications