Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors
Amr K. A. Bass, El-Shimaa M. Nageeb, Mona S. El‐Zoghbi, Mamdouh F. A. Mohamed, Mohamed Badr, Gamal El‐Din A. Abuo‐Rahma
Topics & Concepts
ChemistryMoietyHydroxamic acidIC50StereochemistryCell cycle checkpointLinkerKinaseApoptosisHistone deacetylaseVorinostatAcetylationEnzymeCell cycleIn vitroBiochemistryHistoneGeneComputer scienceOperating systemCancer Mechanisms and TherapyPeptidase Inhibition and AnalysisHistone Deacetylase Inhibitors Research