NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells
Yuetong Wang, Fei Wang, Lihua Wang, Shizhen Qiu, Yufeng Yao, Chenxu Yan, Xuexue Xiong, Xuyong Chen, Quanquan Ji, Jian Cao, Ganglong Gao, Dake Li, Liye Zhang, Zhiqian Guo, Ruoning Wang, Haopeng Wang, Gaofeng Fan
Abstract
could boost T-cell-based immunotherapy.
Topics & Concepts
Nicotinamide phosphoribosyltransferaseNAD+ kinaseT-cell receptorCancer researchCell biologyT cellTumor microenvironmentBiologyImmune checkpointImmunotherapyChemistryBlockadeBiochemistryImmune systemReceptorImmunologyEnzymeTumor cellsCAR-T cell therapy researchCytomegalovirus and herpesvirus researchSirtuins and Resveratrol in Medicine