Optogenetic Stimulation of the Cardiac Vagus Nerve to Promote Heart Regenerative Repair after Myocardial Infarction
Yuan Han, Xiaomin Wei, Guojun Chen, Enge Shao, Yilin Zhou, Yuqing Li, Zhiwen Xiao, Xiaoran Shi, Hao Zheng, Senlin Huang, Yanmei Chen, Yanbing Wang, Yeshen Zhang, Yulin Liao, Wangjun Liao, Jianping Bin, Yuegang Wang, Xinzhong Li
Abstract
Targeting the cardiac vagus nerve by optogenetic stimulation induced macrophage M2 polarization by activating the IL-10/STAT3 signaling pathway, which obviously optimized the regenerative microenvironment and then improved cardiac function after MI.
Topics & Concepts
OptogeneticsVagus nerveVagus nerve stimulationCardiac function curveMyocardial infarctionMedicineRegeneration (biology)StimulationNeuroscienceInternal medicineCardiologyBiologyHeart failureCell biologyVagus Nerve Stimulation ResearchTissue Engineering and Regenerative MedicineNeuroscience and Neural Engineering