Bacteroidetocins Target the Essential Outer Membrane Protein BamA of <i>Bacteroidales</i> Symbionts and Pathogens
Leigh M. Matano, Michael J. Coyne, Leonor García-Bayona, Laurie E. Comstock
Abstract
The bacteroidetocins are a newly discovered class of bacteriocins specific to Bacteroidetes with a spectrum of targets extending from symbiotic gut Bacteroides , Parabacteroides , and Prevotella species to pathogenic oral and vaginal Prevotella species. We previously showed that one such bacteroidetocin, Bd-A, is active at nanomolar concentrations, is water soluble, and is bactericidal, all desirable features in a therapeutic antibacterial peptide.
Topics & Concepts
PrevotellaBacteroidetesBacteroidesMicrobiologyBacteriocinBacterial outer membraneBiologyBamaBacteroidaceaeBacteriaChemistryAntimicrobialBiochemistry16S ribosomal RNAGeneEscherichia coliGeneticsGenomics and Phylogenetic StudiesYersinia bacterium, plague, ectoparasites researchBacterial Identification and Susceptibility Testing