Intracellular Astrocyte Calcium Waves In Situ Increase the Frequency of Spontaneous AMPA Receptor Currents in CA1 Pyramidal Neurons
Todd A. Fiacco, Ken D. McCarthy
Abstract
Spontaneous neurotransmitter release and activation of group I metabotropic glutamate receptors (mGluRs) each play a role in the plasticity of neuronal synapses. Astrocytes may contribute to short- and long-term synaptic changes by signaling to neurons via these processes. Spontaneous whole-cell AMPA receptor (AMPAR) currents were recorded in CA1 pyramidal cells
Topics & Concepts
AMPA receptorNeuroscienceCalcium in biologyAstrocyteCalciumChemistryIntracellularBiophysicsReceptorGlutamate receptorBiologyCentral nervous systemBiochemistryOrganic chemistryNeuroscience and Neuropharmacology ResearchNeuroscience and Neural EngineeringNeural dynamics and brain function