Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement
Mans Broekgaarden, Anne‐Laure Bulin, Estelle Porret, Benjamin Musnier, Benoît Chovelon, Corinne Ravelet, Lucie Sancey, Hélène Elleaume, Pierre Hainaut, Jean‐Luc Coll, Xavier Le Guével
Abstract
Ultra-small gold nanoclusters (AuNCs) are increasingly investigated for cancer imaging and radiotherapy enhancement. While fine-tuning the AuNC surface chemistry can optimize their pharmacokinetics, its effects on radiotherapy enhancement remain largely unexplored. This study demonstrates that optimizing the surface chemistry of AuNCs for increased tumor uptake can significantly affect its potential to augment radiotherapy outcomes.
Topics & Concepts
NanoclustersSurface modificationCancer therapyRadiation therapyNanotechnologyMaterials scienceColloidal goldChemistryNanoparticleCancerMedicineInternal medicinePhysical chemistryNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranostics