Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
Daniel J. Sanderson, Kelsie M. Rodriguez, Daniel S. Bejan, Ninni Elise Olafsen, Inga D. Bohn, Ana Kojic, Sunil K. Sundalam, Ivan Rodriguez Siordia, Anna K. Duell, Nancy Deng, Carsten Schultz, Denis M. Grant, Jason Matthews, Michael S. Cohen
Topics & Concepts
RegulatorBiologyInterferonInnate immune systemSignal transductionFunction (biology)Cell biologyGeneImmune systemEmbryonic stem cellBiochemistryImmunologyPARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisCell death mechanisms and regulation