Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3
Huajun Han, Laurie A. Davidson, Yang‐Yi Fan, Kerstin K. Landrock, Arul Jayaraman, Stephen Safe, Robert S. Chapkin
2021American Journal of Physiology-Gastrointestinal and Liver Physiology22 citationsDOIOpen Access PDF
Abstract
AhR is a key transcription factor controlling expression of IL22 in gut immune cells. In this study, we show for the first time that AhR signaling also regulates IL22 response in colonic epithelial cells by modulating SOCS3 expression.
Topics & Concepts
Interleukin 22Aryl hydrocarbon receptorSOCS3Cell biologySignal transductionDownregulation and upregulationTranscription factorChemistryBiologyCytokineImmunologyBiochemistryGeneSTAT3InterleukinCytokine Signaling Pathways and InteractionsImmune cells in cancerGenomics, phytochemicals, and oxidative stress