Effect of dietary anthocyanins on biomarkers of oxidative stress and antioxidative capacity: A systematic review and meta-analysis of randomized controlled trials
Aziz A. Fallah, Elham Sarmast, Tina Jafari
Abstract
In this study, the efficacy of dietary anthocyanins (ACs) on indices of oxidative stress and antioxidative capacity was evaluated through a meta-analytical approach. meta-analysis of 23 trials indicated that ACs significantly reduced the levels of malondialdehyde (MDA; −0.41, 95% CI: −0.62 to −0.21, P < 0.001), oxidized low-density lipoprotein (Ox-LDL; −0.27, 95% CI: −0.55 to 0.02, P = 0.064), and isoprostane (−0.57, 95% CI: −0.78 to −0.36, P < 0.001) while significantly increased the level of total antioxidative capacity (TAC; 0.32, 95% CI: 0.08 to 0.55, P = 0.008) and activity of superoxide dismutase (SOD; 0.29, 95% CI: 0.07 to 0.51, P = 0.010) and glutathione peroxidase (GPx; 0.59, 95% CI: 0.19 to 1.0, P = 0.004). Compared to healthy subjects, ACs were more useful for unhealthy subjects because of the significant decrease in MDA, Ox-LDL, and isoprostane levels; and significant increase in TAC level and SOD activity. The overall results indicate that dietary ACs alleviate oxidative stress and enhance antioxidative capacity in the subjects.