The Impact of SARS-CoV-2 Variants on the Clinical Phenotype and Severity of Multisystem Inflammatory Syndrome in Children in South Africa
Deepthi Raju Abraham, Claire Butters, Nurea Abdulbari Yunis, Juanita Lishman, Christiaan Scott, Marieke M. van der Zalm, Liesl Zühlke, Helena Rabie, Kate Webb
Abstract
The effects of SARS-CoV-2 variants on disease phenotype and severity of multisystem inflammatory syndrome in children (MIS-C) are unknown. We compared the clinical phenotype of MIS-C in 129 South African children across four distinct (Ancestral type, Beta, Delta, and Omicron) variant-driven waves and found that MIS-C remains a severe disease with a stable clinical presentation, regardless of variant.
Topics & Concepts
PhenotypeDiseaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)MedicineImmunologyClinical phenotypePresentation (obstetrics)BiologyGeneticsPathologyGeneInfectious disease (medical specialty)RadiologyKawasaki Disease and Coronary ComplicationsSARS-CoV-2 and COVID-19 ResearchInflammasome and immune disorders