Synthesis of α-aminophosphonates by the Kabachnik-Fields reaction
G. Sravya, A. Balakrishna, Grigory V. Zyryanov, G. Mohan, C. Suresh Reddy, N. Bakthavatchala Reddy
Abstract
The review discusses recent achievements in the development of more ecofriendly and economically viable processes for the synthesis of biologically potent α-aminophosphonates via Kabachnik-Fields reaction by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These α-aminophosphonates exhibited promising antioxidant, antimicrobial and anticancer activity. Some recent developments on the synthesis of biologically active α-aminophosphonates in the presence of various catalysts, in catalytic solvent medium, in catalyst-free solvent medium, under solvent-free conditions, and reactions in solution are discussed. Miscellaneous reactions are also included.