Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini
Michelle M. Gill, Philisiwe Khumalo, Caspian Chouraya, Mthokozisi Kunene, Futhi Dlamini, Heather J. Hoffman, Angela E. Scheuerle, Bonisile Nhlabatsi, Wiseman Mngometulu, Ntombikayise Dlamini-Madlopha, Nompumelelo Mthunzi, Lynne Mofenson
Abstract
Birth defect surveillance in Eswatini in 2020-2021 identified 0.80% defects (197/24 599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4902 women on dolutegravir preconception, 17 285 HIV-negative women, and 1320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.
Topics & Concepts
DolutegravirMedicineNeural tubeHuman immunodeficiency virus (HIV)ObstetricsPediatricsAntiretroviral therapyEmergency medicineEnvironmental healthVirologyViral loadBiologyCell biologyEmbryoPregnancy and preeclampsia studiesFolate and B Vitamins ResearchGlobal Maternal and Child Health