Towards Personalized TSH Reference Ranges: A Genetic and Population-Based Approach in Three Independent Cohorts
Aleksander Kuś, Rosalie Sterenborg, Eirin B. Haug, Tessel E. Galesloot, W. Edward Visser, Johannes W. A. Smit, Tomasz Bednarczuk, Robin P. Peeters, Bjørn Olav Åsvold, Alexander Teumer, Marco Medici, Alexander Teumer, Marco Medici, Marco Medici
Abstract
Individual genetic profiles have the potential to personalize TSH reference ranges, with large effects on reclassification of diagnosis and LT4 prescriptions. As the currently used PGS can only predict approximately 10% of inter-individual variation in TSH concentrations, it should be further improved when more genetic variants determining TSH concentrations are identified in future studies.
Topics & Concepts
PopulationMedicineBiologyDemographyComputer scienceComputational biologyInternal medicineStatisticsMathematicsEnvironmental healthSociologyThyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsNeuroscience of respiration and sleep