Thioamide synthesis <i>via</i> copper-catalyzed C–H activation of 1,2,3-thiadiazoles enabled by slow release and capture of thioketenes
Changhui Lu, Xiaohong Li, Shun-Qin Chang, Yuqi Zhang, Donghui Xing, Shuo Wang, Yueping Lin, Huanfeng Jiang, Liangbin Huang
Abstract
A copper-catalyzed coupling of 1,2,3-thiadiazoles with various amines under base-free conditions was developed as a robust protocol for the synthesis of thioamide derivatives via C–H activation/Cu coordination strategy.
Topics & Concepts
ThioamideThiadiazolesChemistryCatalysisCopperBase (topology)Combinatorial chemistryMedicinal chemistryOrganic chemistryMathematicsMathematical analysisSynthesis of heterocyclic compoundsSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods