A generator of peroxynitrite activatable with red light
Cristina Parisi, Mariacristina Failla, Aurore Fraix, Luca Menilli, Francesca Moret, Elena Reddi, Barbara Rolando, Francesca Spyrakis, Loretta Lazzarato, Roberta Fruttero, Alberto Gasco, Salvatore Sortino
Abstract
Excitation of a molecular hybrid with highly biocompatible red light generates cytotoxic peroxynitrite, produces red fluorescence useful for cell tracking and induces remarkable cancer cell death at very low concentrations and very low light doses.
Topics & Concepts
PeroxynitriteFluorescenceChemistryRed lightBiophysicsCytotoxic T cellCytotoxicityRed CellBiocompatible materialPhotochemistryNanotechnologyBiochemistryMaterials scienceBiologyOpticsMedicineBiomedical engineeringIn vitroPhysicsEnzymeInternal medicineBotanySuperoxideNanoplatforms for cancer theranosticsNitric Oxide and Endothelin EffectsMolecular Sensors and Ion Detection