Litcius/Paper detail

Synthesis of 11-aminoalkoxy substituted benzophenanthridine derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their anticancer activity

Hao Yang, Fang‐Ting Wang, Min Wu, Wenjie Wang, Keli Agama, Yves Pommier, Lin‐Kun An

2022Bioorganic Chemistry11 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryTopoisomeraseDNAPhosphodiesteraseTopotecanIC50EnzymeCancer cellCell cultureBiochemistryCancerIn vitroGeneticsChemotherapyBiologyCancer therapeutics and mechanismsNeutropenia and Cancer InfectionsBioactive Compounds and Antitumor Agents