Synthesis of 11-aminoalkoxy substituted benzophenanthridine derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their anticancer activity
Hao Yang, Fang‐Ting Wang, Min Wu, Wenjie Wang, Keli Agama, Yves Pommier, Lin‐Kun An
Topics & Concepts
ChemistryTopoisomeraseDNAPhosphodiesteraseTopotecanIC50EnzymeCancer cellCell cultureBiochemistryCancerIn vitroGeneticsChemotherapyBiologyCancer therapeutics and mechanismsNeutropenia and Cancer InfectionsBioactive Compounds and Antitumor Agents