A role for keratins in supporting mitochondrial organization and function in skin keratinocytes
Kaylee Steen, Desu Chen, Feng‐Rong Wang, Ritankar Majumdar, Song Chen, Surinder Kumar, David B. Lombard, Roberto Weigert, Abigail Zieman, Carole A. Parent, Pierre A. Coulombe
Abstract
exhibit elevated ROS, reduced mitochondrial respiration, intracellular distribution differences, and altered movement of mitochondria within the cell. These findings highlight a novel role for K6 and K16 in regulating mitochondrial morphology, dynamics, and function and shed new light on the causes of oxidative stress observed in PC and related keratin-based skin disorders.
Topics & Concepts
BiologyKeratinCell biologyFunction (biology)MitochondrionKeratinocyteComputational biologyGeneticsCell cultureSkin and Cellular Biology ResearchFibroblast Growth Factor ResearchHair Growth and Disorders