Blocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells
Md Nabiul Hasan, Lanxin Luo, Dawei Ding, Shanshan Song, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Lesley M. Foley, Xiudong Guan, Gary Kohanbash, T. Kevin Hitchens, María G. Castro, Zhongling Zhang, Dandan Sun
Abstract
NHE1 plays a role in developing glioma immunosuppressive TME in part by dysregulating glucose metabolism of GAMs and emerges as a therapeutic target for improving glioma immunity.
Topics & Concepts
GliomaTemozolomideTumor microenvironmentCancer researchAnaerobic glycolysisMyeloidGlycolysisPharmacologyChemistryBiologyMetabolismBiochemistryTumor cellsGlioma Diagnosis and TreatmentEpigenetics and DNA MethylationHistone Deacetylase Inhibitors Research