Modified cereal bran (MCB) from finger millet, kodo millet, and rice bran prevents high-fat diet-induced metabolic derangements
Kirti Devi, Vibhu Kumar, Vijay Kumar, Neha Mahajan, Jasleen Kaur, Shikha Sharma, Ajay Kumar, Rehan Khan, Mahendra Bishnoi, Kanthi Kiran Kondepudi
Abstract
gut permeability assay, immunohistochemistry of tight junction proteins, and gene expression analysis in the colon revealed that the combination of three brans was better in preventing HFD-induced leaky gut in comparison to the individual brans. Hierarchical clustering analysis showed that the combination group was clustered closest to the NPD group, suggesting an additive effect. Our study implies that a combination of mFMB, mKMB, and mRB could be used as a nutraceutical or functional food ingredient for preventing HFD-induced gut derangements and associated metabolic complications.
Topics & Concepts
BranFood scienceRuminococcusAkkermansiaGut floraLachnospiraceaeBiologyAdipose tissueFirmicutesChemistryBiochemistryFermentationLactobacillusEcologyRaw material16S ribosomal RNAGeneDiet and metabolism studiesAdipokines, Inflammation, and Metabolic DiseasesNutritional Studies and Diet