Synthesis of 1,3,4-Thiadiazoles and 1,4,2-Oxathiazoles from α-Enolic Dithioesters and Active 1,3-Dipoles
Bin Cheng, Hui Li, Jianguo Sun, Xinping Zhang, Yixuan He, Haiyan Sun, Wei Xu, Taimin Wang, Hongbin Zhai
Abstract
The synthesis of two kinds of five-membered organosulfur heterocycles (i.e., 1,4,2-oxathiazoles and 1,3,4-thiadiazoles) from α-enolic dithioesters with active 1,3-dipoles (nitrile oxides and nitrilimines) generated in situ was achieved under mild reaction conditions. This transformation further expands the synthetic application of α-enolic dithioesters as the sulfur-containing building blocks.
Topics & Concepts
ChemistryThiadiazolesOrganosulfur compoundsNitrileDipoleSulfurOrganic chemistryCombinatorial chemistrySulfur-Based Synthesis TechniquesSynthesis of heterocyclic compoundsSynthesis and Catalytic Reactions