The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis
Abolfazl Mehdizadehkashi, Samaneh Rokhgireh, Kobra Tahermanesh, Neda Eslahi, Sara Minaeian, Mansooreh Samimi
Abstract
Background To our knowledge, data on the effects of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis are limited. This study was conducted to determine the effects of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis.Methods The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 18–40 years old) with endometriosis. Participants were randomly allocated into two groups (30 participants each group) to receive either 50,000 IU vitamin D or placebo each 2 weeks for 12 weeks.Results Vitamin D supplementation significantly decreased pelvic pain (β − 1.12; 95% CI, −2.1, −0.09; p=.03) and total-/HDL-cholesterol ratio (β − 0.29; 95% CI, −0.57, −0.008; p=.04) compared with the placebo. Moreover, vitamin D intake led to a significant reduction in high-sensitivity C-reactive protein (hs-CRP) (β − 0.64 mg/L; 95% CI, −0.97, −0.30; p<.001) and a significant increase in total antioxidant capacity (TAC) (β 47.54 mmol/L; 95% CI, 19.98, 75.11; p=.001) compared with the placebo.Conclusions Overall, our study demonstrated that vitamin D intake in patients with endometriosis resulted in a significant improvement of pelvic pain, total-/HDL-cholesterol ratio, hs-CRP and TAC levels, but did not affect other clinical symptoms and metabolic profiles.