The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
Kijeong Lee, Sang Hag Lee, Tae Hoon Kim
Abstract
Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.
Topics & Concepts
CyclooxygenaseProstaglandin D2ReceptorAsthmaLipid signalingImmunologyEicosanoidAspirinThromboxane A2Arachidonic acidProstaglandin E2 receptorMedicineDiseaseProstaglandinThromboxaneAirwayInflammationBiologyPlateletEndocrinologyInternal medicineBiochemistryAgonistEnzymeAnesthesiaAsthma and respiratory diseasesInflammatory mediators and NSAID effectsUrticaria and Related Conditions