IL-7R signaling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells
Amanda Baizan-Edge, Bryony A. Stubbs, Michael J. T. Stubbington, Daniel J. Bolland, Kristina Tabbada, Simon Andrews, Anne E. Corcoran
Abstract
B cells. Thus, in addition to its roles in survival and proliferation, IL-7R signaling shapes the Igh repertoire by activating underpinning mechanisms.
Topics & Concepts
BiologyRepertoireGeneTranscription factorAntibodyPAX5RecombinationLocus (genetics)GeneticsMolecular biologyAcousticsPhysicsT-cell and B-cell ImmunologyImmune Cell Function and InteractionDiabetes and associated disorders