Visible‐Light‐Driven Sulfonylation/Cyclization to Access Sulfonylated Benzo[4,5]imidazo[2,1‐<i>a</i>]isoquinolin‐6(5<i>H</i>)‐ones
Chen Wang, Guo‐Quan Sun, Hong‐Li Huang, Jing Liu, Hua Tang, Yinghua Li, Honggang Hu, Shipeng He, Fei Gao
Abstract
Visible-light-driven sulfonylation/cyclization of N-methacryloyl-2-phenylbenzoimidazoles has been successfully developed. Using commercially available sulfonyl chloride as sulfonylation reagent, a wide range of sulfonylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones with potential antitumor activity were provided in acceptable to excellent yields. This method has the advantages of mild reaction conditions and outstanding functional group tolerance, and provides a new strategy for the development of potential antitumor lead compounds.
Topics & Concepts
ReagentChemistryChlorideSulfonylCombinatorial chemistryVisible spectrumMedicinal chemistryOrganic chemistryOptoelectronicsMaterials scienceAlkylSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions