Design, synthesis, and biological activity studies on benzimidazole derivatives targeting myeloperoxidase
Merve Saylam, Fadime Aydın Köse, Aysun Pabuçcuoğlu, Duygu Barut Celepci, Muhíttín Aygün, Varol Pabuççuoğlu
Topics & Concepts
ChemistryMyeloperoxidaseBenzimidazoleHypochlorous acidBiochemistryHydrazideHydroxamic acidImidazoleEnzymeReactive nitrogen speciesStereochemistryPharmacologyReactive oxygen speciesInflammationOrganic chemistryImmunologyBiologyMedicineNeutrophil, Myeloperoxidase and Oxidative MechanismsSynthesis and biological activitySynthesis and Biological Evaluation