Reprogramming the metabolism of oleaginous yeast for sustainably biosynthesizing the anticarcinogen precursor germacrene A
Qi Liu, Ge Zhang, Liqiu Su, Pi Liu, Shiru Jia, Qinhong Wang, Zongjie Dai
Abstract
The highest titer of the anticancer precursor sesquiterpene germacrene A was observed in oleaginous yeast using multi-layered systematic metabolic engineering strategies.
Topics & Concepts
ChemistryReprogrammingMetabolismSustainabilityYeastBiochemistryGermacreneFood scienceBiologyGeneEcologyEssential oilPlant biochemistry and biosynthesisMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and Immobilization