Systematic dissection of coordinated stromal remodeling identifies Sox10+ glial cells as a therapeutic target in myelofibrosis
Shawn Sarkaria, Junsong Zhou, Suying Bao, Wenqi Zhao, Yinshan Fang, Jianwen Que, Govind Bhagat, Chaolin Zhang, Lei Ding
Topics & Concepts
BiologyMyelofibrosisStromal cellBone marrowFibrosisCancer researchCell biologyHaematopoiesisMyofibroblastMesenchymal stem cellPericytePDGFRAPDGFRBPathologyImmunologyStem cellEndothelial stem cellMedicineGeneGeneticsGiSTIn vitroMyeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia ResearchPlatelet Disorders and Treatments