Janus -faced oxidant and antioxidant profiles of organo diselenides
Aditya Upadhyay, Raushan Kumar Jha, Monojit Batabyal, Tanoy Dutta, Apurba Lal Koner, Sangit Kumar
Abstract
MTT assay, which suggests that the compounds are effective at 15-18 μM concentration against cancer cells. Moreover, the combination with therapeutic anticancer drugs Erlotinib and Doxorubicin showed promising cytotoxicity at the nanomolar concentration (8-28 nM), which is sufficient to suppress the growth of the cancer cells.
Topics & Concepts
Pro-oxidantJanusChemistryAntioxidantNanotechnologyMaterials scienceBiochemistryOrganoselenium and organotellurium chemistryFree Radicals and AntioxidantsChemical Thermodynamics and Molecular Structure