Identification and Characterization of Rift Valley Fever Virus-Specific T Cells Reveals a Dependence on CD40/CD40L Interactions for Prevention of Encephalitis
Dominique J. Barbeau, Haley N. Cartwright, Jessica R. Harmon, Jessica R. Spengler, Christina F. Spiropoulou, John Sidney, Alessandro Sette, Anita K. McElroy
Abstract
The prevention of RVFV encephalitis requires intact adaptive immunity. In this study, we developed reagents to detect RVFV-specific T cells and provide evidence for Tfh cells and CD40/CD40L interactions as critical mediators of this protection.
Topics & Concepts
BiologyVirologyCD8Cytotoxic T cellEpitopeEncephalitisRift Valley feverMajor histocompatibility complexImmunityImmunologyViral encephalitisAntibodyT cellVirusImmune systemArbovirusInterferonSpleenPhenotypeViral replicationAcquired immune systemInterferon gammaAntigenCellular immunityViral proteinT lymphocyteInterleukin 21MHC class IHuman leukocyte antigenBunyaviridaeViral Infections and VectorsViral Infections and Outbreaks ResearchMosquito-borne diseases and control