Rapid and column-chromatography-free peptide chain elongation <i>via</i> a one-flow, three-component coupling approach
Naoto Sugisawa, Akira Ando, Shinichiro Fuse
Abstract
Rapid (<minutes), mild (20 °C), inexpensive, and column-chromatography-free peptide chain elongation via a one-flow, three-component coupling approach using amino acid chloride, α-amino acid N -carboxy anhydride and amino acid ester was achieved.
Topics & Concepts
Component (thermodynamics)Coupling (piping)Flow (mathematics)PeptideChemistryElongationColumn (typography)ChromatographyColumn chromatographyChain (unit)Biological systemMaterials scienceComputer sciencePhysicsMechanicsBiochemistryBiologyThermodynamicsMetallurgyTelecommunicationsAstronomyUltimate tensile strengthFrame (networking)Chemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies ResearchAnalytical Chemistry and Chromatography