The influence of <i>Helicobacter pylori</i> , proton pump inhibitor, and obesity on the gastric microbiome in relation to gastric cancer development
Chengliang Zhou, Tanya M. Bisseling, Rachel S. van der Post, Annemarie Boleij
Abstract
microbiota contributing to GC are linked to lipopolysaccharide production, contribution to inflammatory pathways, and the formation of N-nitroso compounds and reactive oxygen species. In conclusion, the knowledge of the gastric microbiome in GC is mainly descriptive and based on sequencing of gastric mucosal samples. For a better mechanistic understanding of microbes in GC development, longitudinal cohorts including precancerous lesions, different regions in the stomach, and subtypes of GC, and gastric organoid models for diffuse and intestinal type GC should be employed.
Topics & Concepts
Helicobacter pyloriPrevotellaMicrobiomeCancerProton-pump inhibitorBiologyChronic gastritisStreptococcusGastritisMicrobiologyInternal medicineGastroenterologyMedicineBioinformaticsBacteriaGeneticsHelicobacter pylori-related gastroenterology studiesGastric Cancer Management and OutcomesGut microbiota and health