LC–PDA–MS/MS-Based Dereplication Guided Isolation of a New Optical Isomer of 19,20-Epoxycytochalasin-N and Its Cytotoxic Activity
Manoj Kushwaha, Arem Qayum, Nisha Sharma, Vidushi Abrol, Poonam Choudhary, Mohd Murtaza, Shashank Singh, Ram A. Vishwakarma, Umesh Goutam, Shreyans K. Jain, Sundeep Jaglan
Abstract
values ranging from 1.34 to 19.02 μM. This study shows a fast approach for dereplicating and identifying novel cytochalasin metabolites in crude extracts.
Topics & Concepts
Isolation (microbiology)Cytotoxic T cellChemistryCombinatorial chemistryTraditional medicineChromatographyBiologyMicrobiologyMedicineIn vitroBiochemistryNatural product bioactivities and synthesisBioactive Compounds and Antitumor AgentsMarine Sponges and Natural Products