Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules
Isabelle S. Kurnik, Natália A. D'Angelo, Priscila Gava Mazzola, Marlus Chorilli, Daniel T. Kamei, Jorge F. B. Pereira, António A. Vicente, André Moreni Lopes
Abstract
value for the [Ch][Hex] version corresponded to a greater potency compared to the [Ch]Cl version, since a lower concentration of CCM was required to achieve the same therapeutic effect. The ATPMSs investigated in this study serve as a novel platform for Pluronic® L35/PBS buffer (pH 7.4) + IL-based ATPMS development. The unique properties reported here may be useful in applications such as controlled-release drug delivery systems (DDS), encapsulation, and bioseparations.
Topics & Concepts
MicelleAmphiphileCopolymerIonic liquidPoloxamerChemistryIonic bondingEncapsulation (networking)Chemical engineeringMoleculeAmphiphilic moleculeControlled releaseHydrophobePolymer chemistryOrganic chemistryPolymerAqueous solutionBiochemistryCatalysisIonComputer scienceComputer networkEngineeringSurfactants and Colloidal SystemsCurcumin's Biomedical ApplicationsIonic liquids properties and applications