Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature
Rehan Farooqi, A. N. Kamal, Carol A. Burke
Abstract
Mycophenolate mofetil (MMF) is an immunosuppressive medication used for the management of various autoimmune diseases, and patients with bone marrow and solid organ transplants. Gastrointestinal side effects are seen 45% of the time and they include nausea (29%), vomiting (23%), constipation (38%), diarrhea (50%-92%), and colitis (9%). In 98% of cases, resolution of diarrhea occurs within 20 days upon discontinuation of the MMF. Data is scarce regarding approach in the treatment of MMF-induced colitis. We report a case of MMF-induced colitis diagnosed by colonoscopy and histopathology. This case illustrates the challenges encountered while managing MMF-induced colitis.
Topics & Concepts
MedicineColitisDiarrheaDiscontinuationConstipationColonoscopyVomitingGastroenterologyInflammatory bowel diseaseMicroscopic colitisNauseaInternal medicineMycophenolateHistopathologyTransplantationPathologyColorectal cancerDiseaseCancerRenal Transplantation Outcomes and TreatmentsLiver Diseases and ImmunityMycobacterium research and diagnosis