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Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway

Yutong Han, Yunqian Xian, Xiaomeng Gao, Panpan Qiang, Juan Hao, Fan Yang, Tatsuo Shimosawa, Yi Chang, Qingyou Xu

2022International Immunopharmacology15 citationsDOI

Topics & Concepts

EplerenoneCTGFMineralocorticoid receptorMedicineCardiac fibrosisFibrosisInternal medicineEndocrinologyCardiorenal syndromeKidney diseaseSpironolactoneAldosteronePharmacologyReceptorGrowth factorPulmonary Hypertension Research and TreatmentsConnective Tissue Growth Factor ResearchCardiovascular, Neuropeptides, and Oxidative Stress Research
Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway | Litcius