HN1L/JPT2: A signaling protein that connects NAADP generation to Ca <sup>2+</sup> microdomain formation
Hannes Roggenkamp, Imrankhan Khansahib, Lola C. Hernandez, Yunpeng Zhang, Dmitri Lodygin, Aileen Krüger, Feng Gu, Franziska Möckl, Anke Löhndorf, Valerie Wolters, Daniel Woike, Anette Rosche, Andreas Bauche, Daniel Schetelig, René Werner, Hartmut Schlüter, Antonio Virgilio Failla, Chris Meier, Ralf Fliegert, Timothy F. Walseth, Alexander Flügel, Björn‐Philipp Diercks, Andreas H. Guse
Abstract
A protein that enables the activation of ryanodine receptors by NAADP in T cells is identified.
Topics & Concepts
Lipid microdomainRyanodine receptorCell biologyReceptorChemistrySignal transductionBiologyBiochemistryMembraneCalcium signaling and nucleotide metabolism