The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance.
Melanie Heinlein, Luke C. Gandolfo, Kelin Zhao, Charis E. Teh, Nghi Nguyen, Jonathan B. Baell, Yael Goldfarb, Jakub Abramson, Johannes Wichmann, Anne K. Voss, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Daniel H.D. Gray
Abstract
-deficient mice. These findings highlight critical roles for KAT7-mediated acetylation in promoting a chromatin state at PTG loci that enables AIRE function and the establishment of immunological tolerance.
Topics & Concepts
BiologyAutoimmune regulatorCentral toleranceChromatinHistone acetyltransferaseHistoneTranscription factorCell biologyAcetylationGeneGeneticsImmunologyCancer researchImmune toleranceAntigenAdrenal Hormones and DisordersEstrogen and related hormone effects