Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis
Min-Jung Lee, Yoon Mee Park, Byunghyun Kim, In Hwan Tae, Nam-Eun Kim, Marina Pranata, Tae‐Won Kim, Sungho Won, Nam Joo Kang, Yun Kyung Lee, Dong‐Woo Lee, Myung Hee Nam, Soo‐Jong Hong, Bong Soo Kim
Abstract
cell assays. Although the gut microbiome maturated with age in both AD and non-AD groups, its development was disordered in the AD group. Disordered colonization of short-chain fatty acids (SCFA) producers along with age led to abnormal SCFA production and increased IgE levels. A butyrate deficiency and downregulation of GPR109A and PPAR-γ genes were detected in AD-induced mice. Insufficient butyrate decreases the oxygen consumption rate of host cells, which can release oxygen to the gut and perturb the gut microbiome. The disordered gut microbiome development could aggravate balanced microbiome-host interactions, including immune responses during early childhood with AD.