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Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers

Heba K. Abd El-Mawgoud, Asmaa M. AboulMagd, Mohamed T. M. Nemr, Magdy M. Hemdan, Aya I. Hassaballah, Paula S. Farag

2024Bioorganic Chemistry28 citationsDOI

Topics & Concepts

ChemistryAutophagyApoptosisPyrimidineInducerCytotoxic T cellProtein kinase BVEGF receptorsPI3K/AKT/mTOR pathwayStereochemistryDual (grammatical number)Combinatorial chemistryCancer researchBiochemistryIn vitroArtGeneBiologyLiteratureBioactive Compounds and Antitumor AgentsSynthesis and biological activityPI3K/AKT/mTOR signaling in cancer
Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers | Litcius