Development and validation of ultra-performance liquid chromatography-tandem mass spectrometric methods for simultaneous and rapid determination of contezolid and its major metabolite M2 in plasma and urine samples and its application to a study in subjects with moderate liver impairment
Yu Wang, Hailan Wu, Junzhen Wu, Yaxin Fan, Xiaofen Liu, Yi Li, Jiali Hu, Jing Zhang, Beining Guo
Topics & Concepts
ChromatographyChemistryMetaboliteUrineHigh-performance liquid chromatographyPharmacokineticsSolid phase extractionAnalyteExtraction (chemistry)Detection limitTandem mass spectrometryAntibacterial agentLiquid chromatography–mass spectrometrySelected reaction monitoringMass spectrometryAntibioticsPharmacologyBiochemistryMedicineAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in StaphylococcusAnalytical Methods in Pharmaceuticals