Accelerated Storage for Shelf-Life Prediction of Lyophiles: Temperature Dependence of Degradation of Amorphous Small Molecular Weight Drugs and Proteins
Evgenyi Shalaev, Satoshi Ohtake, Ehab M. Moussa, Jim Searles, Steven L. Nail, Christopher J. Roberts
Topics & Concepts
Arrhenius equationExtrapolationArrhenius plotAmorphous solidDegradation (telecommunications)ThermodynamicsGlass transitionRelaxation (psychology)DiffusionChemistryActivation energyAtmospheric temperature rangeReaction rate constantKineticsPhysical chemistryOrganic chemistryPolymerMathematicsStatisticsPhysicsComputer sciencePsychologyQuantum mechanicsSocial psychologyTelecommunicationsProtein purification and stabilityDrug Solubulity and Delivery SystemsMicroencapsulation and Drying Processes