Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of <i>N</i>-Acyliminium Ions
Ashley J. Basson, Mark McLaughlin
Abstract
Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields.
Topics & Concepts
NucleophileTrappingCatalysisIonCalciumSulfurChemistryCombinatorial chemistryCarbon fibersNitrogenMaterials scienceOrganic chemistryEcologyComposite numberComposite materialBiologySynthesis and pharmacology of benzodiazepine derivativesAdvanced Synthetic Organic ChemistryCoordination Chemistry and Organometallics