The tyrosine kinase c-Abl potentiates interferon-mediated antiviral immunity by STAT1 phosphorylation
Hainan Liu, Yan Cui, Yu Bai, Yi Fang, Ting Gao, Guangfei Wang, Lin Zhu, Qincai Dong, Shuwei Zhang, Yi Yao, Caiwei Song, Xiayang Niu, Yanwen Jin, Ping Li, Cheng Cao, Xuan Liu
Abstract
) deficiency significantly suppresses antiviral responses in vesicular stomatitis virus-infected cells. Compared to vehicle, administration of the c-Abl/Arg selective inhibitor AMN107 resulted in significantly increased mortality in mice infected with human influenza virus. Our study demonstrates that c-Abl plays an essential role in the STAT1 activation signaling pathway and provides an important approach for antiviral immunity regulation.
Topics & Concepts
STAT1STAT proteinPhosphorylationABLJanus kinaseTyrosine phosphorylationInterferonBiologyIRF1IRF7Vesicular stomatitis virusSignal transductionCell biologyKinaseInterferon regulatory factorsIRF8Tyrosine kinaseCancer researchSTAT3VirologyTranscription factorVirusBiochemistryGeneCytokine Signaling Pathways and InteractionsMonoclonal and Polyclonal Antibodies ResearchProtein Kinase Regulation and GTPase Signaling