Combining flavin photocatalysis with parallel synthesis: a general platform to optimize peptides with non-proteinogenic amino acids
Jacob R. Immel, Maheshwerreddy Chilamari, Steven Bloom
Abstract
the unique combination of boronic acids and a dehydroalanine residue in a peptide. We showcase the power of our newly minted platform to introduce NPAAs of diverse chemotypes-aliphatic, aromatic, heteroaromatic-directly into peptides, including 15 entirely new residues, and to evolve a simple proteinogenic peptide into an unnatural inhibitor of thrombin by non-classical peptide SAR.
Topics & Concepts
Flavin groupAmino acidPhotocatalysisCombinatorial chemistryChemistryNanotechnologyMaterials scienceBiochemistryCatalysisEnzymeChemical Synthesis and AnalysisClick Chemistry and ApplicationsRadical Photochemical Reactions