Role of the Transcriptional Regulator ArgR in the Connection between Arginine Metabolism and c-di-GMP Signaling in Pseudomonas putida
Laura Barrientos‐Moreno, María Antonia Molina‐Henares, María Isabel Ramos‐González, Manuel Espinosa‐Urgel
Abstract
Identifying the molecular mechanisms by which metabolic and environmental signals influence the turnover of the second messenger c-di-GMP is key to understanding the regulation of bacterial lifestyles. The results presented here point at the transcriptional regulator ArgR as a central node linking arginine metabolism and c-di-GMP signaling and indicate the existence of a complex balancing mechanism that connects cellular arginine contents and second messenger levels, ultimately controlling the lifestyles of Pseudomonas putida.
Topics & Concepts
Pseudomonas putidaRegulatorRepressorTranscriptional regulationBiologyCell biologySignal transductionSecond messenger systemMetabolismBiochemistryChemistryEnzymeTranscription factorGeneBacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyBacteriophages and microbial interactions