Mitochondria-targeting monofunctional platinum(<scp>ii</scp>)–lonidamine conjugates for cancer cell de-energization
Muhammad Nafees, Cai‐Ping Tan, Kamran I. Muhammad, Jie Wang, Sadia Nasreen, Zhengyin Pan, Liang-Nian Ji, Zong‐Wan Mao
Abstract
We report the rational design and anticancer mechanism studies of novel mitochondria-targeting monofunctional Pt(<sc>ii</sc>)–lonidamine conjugates for the selective de-energization of cancer cells.
Topics & Concepts
MitochondrionConjugateChemistryCancer cellRational designPlatinumCellCombinatorial chemistryBiochemistryBiophysicsCell biologyCancerBiologyNanotechnologyMaterials scienceMathematicsCatalysisGeneticsMathematical analysisMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsMolecular Junctions and Nanostructures