Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy
Kanwal Asif, Muhammad Adeel, Md. Mahbubur Rahman, Isabella Caligiuri, Tiziana Perin, Maja Čemažar, Vincenzo Canzonieri, Flavio Rizzolio
Abstract
. This work presents the effective therapeutic application of FeNP as an efficient Fenton agent along with ferroptosis inducer activity to improve CDT, through disturbing redox homeostasis.
Topics & Concepts
GPX4ChemistryOxidative stressCancer cellReactive oxygen speciesGlutathioneInducerLipid peroxidationBiochemistryCell biologyCancer researchCancerEnzymeBiologyGlutathione peroxidaseCatalaseGeneGeneticsNanoplatforms for cancer theranosticsFerroptosis and cancer prognosisPregnancy and preeclampsia studies