Neurologic Complications of Cancer Immunotherapy
Aseel Alsalem, Leslie A. Scarffe, Hannah Briemberg, Ashley Aaroe, Rebecca A. Harrison
Abstract
Immunotherapy has revolutionized cancer treatment over the past decade. As it is increasingly introduced into routine clinical practice, immune-related complications have become more frequent. Accurate diagnosis and treatment are essential, with the goal of reduced patient morbidity. This review aims to discuss the various clinical manifestations, diagnosis, treatments, and prognosis of neurologic complications associated with the use of immune checkpoint inhibitors, adoptive T-cell therapies, and T-cell redirecting therapies. We also outline a suggested clinical approach related to the clinical use of these agents.
Topics & Concepts
MedicineImmunotherapyIntensive care medicineCancerClinical PracticeCancer immunotherapyCancer treatmentInternal medicinePhysical therapyCAR-T cell therapy researchCancer Immunotherapy and BiomarkersGlioma Diagnosis and Treatment