The Roles of Alternative Splicing in Tumor-immune Cell Interactions
Yue Wang, Honglei Zhang, Baowei Jiao, Jian‐Yun Nie, Xi‐Yin Li, Wenhuan Wang, Hairui Wang
Abstract
Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and protumoral roles in different types of cancer. For example, ULBP1_RI, MLL5Δ21spe, NKp44-1Δ5, MHC-IΔ7, CD200SΔ1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers.
Topics & Concepts
Immune systemAlternative splicingRNA splicingNeuroscienceComputational biologyBiologyCell biologyImmunologyGeneticsGeneRNAMessenger RNARNA Research and SplicingImmune Cell Function and InteractionCAR-T cell therapy research